Discuss the recent advances, advantages and disadvantages of different CRB1 human and animal retinal degeneration models.

Retinal death can be caused by several genes. When there is an error in the CRB1 gene, some people become severely visually impaired.

These findings show that the rare CRB1 variant, c.498_506del, is strongly associated with localised retinal dysfunction.

Data show that CRB1 mutations are a relatively frequent cause of early-onset retinal degeneration in the Israeli and Palestinian population.

CLRN1, is a four-transmembrane protein predicted to be associated with ribbon synapses of photoreceptors and cochlear hair cells,